Many reports of the past 20 years have highlighted the unique properties of the solid-state fluorophore HPQ, also known as “ELF 97 alcohol”. HPQ is a highly attractive candidate for the incorporation into enzyme-responsive molecular probes that furnish high sensitivity, rapid response, and signal retention. But HPQ has unfavorable chemical properties with regard to its incorporation into stable and robust molecular probes. Hence, a single probe has hitherto been marketed, responding to generic phosphatase activity. It is here that Molsid’s innovative chemical technology changes the game by offering robust probes for many enzyme activities.